Hepatitis C virus cell culture adaptive mutations enhance cell culture propagation by multiple mechanisms but boost antiviral responses in primary human hepatocytes
N. Frericks, R. J. P. Brown, B. M. Reinecke, M. Herrmann, Y. Brueggemann, D. Todt, C. Miskey, F. Vondran, E. Steinmann, T. Pietschmann, J. A. Sheldon
This study identifies cell culture adaptive mutations in HCV that enhance replicative fitness in cell lines but reduce virion production in primary human hepatocytes by boosting antiviral responses.
bioRxiv · Nov 22, 2023 · PreprintMolecular Biology