Author

T. Pietschmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2 Cell Biology· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 5 Assay:bulk RNA-seq· 4 Approach:experimental assay· 4 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

D. Todt· 3 shared B. Wiegmann· 2 shared C. Miskey· 2 shared E. Steinmann· 2 shared G. Vieyres· 2 shared M. Herrmann· 2 shared R. J. P. Brown· 2 shared S. Haid· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMolecular Biology

D. Todt

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Hepatitis C virus cell culture adaptive mutations enhance cell culture propagation by multiple mechanisms but boost antiviral responses in primary human hepatocytes

N. Frericks, R. J. P. Brown, B. M. Reinecke, M. Herrmann, Y. Brueggemann, D. Todt, C. Miskey, F. Vondran, E. Steinmann, T. Pietschmann, J. A. Sheldon

This study identifies cell culture adaptive mutations in HCV that enhance replicative fitness in cell lines but reduce virion production in primary human hepatocytes by boosting antiviral responses.

bioRxiv · Nov 22, 2023 · PreprintMolecular Biology

Hepatitis D virus infection of stem cell-derived hepatocytes triggers an IFN- and NFkB-based innate immune response unable to clear infection.

F. Lange, J. Garn, H. Anagho, T. von Hahn, T. Pietschmann, A. Carpentier

This paper shows that HDV infects stem cell-derived hepatocytes via NTCP and triggers an IFN and NFkB innate response that fails to clear the infection.

bioRxiv · Aug 11, 2022 · PreprintImmunology

Repurposing screen highlights broad-spectrum coronavirus antivirals and their host targets

S. Haid, A. Matthaei, M. Winkler, S. M. Sake, A. P. Gunesch, J. Rueckert, G. Vieyres, D. Kuehl, T.-T. Nguyen, L. Lasswitz, F. Zapatero, G. Brogden, G. Gerold, B. Wiegmann, U. Bilitewski, , T. Pietschmann

The paper screens a drug library to identify broad-spectrum coronavirus antivirals and their host targets, finding compounds that inhibit both alpha- and beta-coronaviruses.

bioRxiv · Jul 14, 2021 · PreprintMicrobiology

Differential interferon-α subtype immune signatures suppress SARS-CoV-2 infection

J. Schuhenn, T. L. Meister, D. Todt, T. Bracht, K. Schork, J.-N. Billaud, C. Elsner, N. Heinen, Z. Karakoese, S. Haid, S. Kumar, L. Brunotte, M. Eisenacher, J. Chen, Z. Yuan, , S. Pfaender

The paper identifies differential antiviral effects of IFN-alpha subtypes against SARS-CoV-2 and highlights IFN5's superior activity, suggesting therapeutic potential.

bioRxiv · May 20, 2021 · PreprintCell Biology

Initial HCV infection of adult hepatocytes triggers a temporally structured transcriptional program containing diverse pro- and anti-viral elements

B. Tegtmeyer, G. Vieyres, D. Todt, C. Lauber, C. Ginkel, M. Engelmann, M. Herrmann, C. K. Pfaller, F. W. R. Vondran, R. Broering, E. Vafadarnejad, A.-E. Saliba, C. Puff, W. Baumgärtner, C. Miskey, , R. J. P. Brown

This study identifies temporally structured transcriptional changes in HCV-infected human hepatocytes, revealing both antiviral and pro-viral programs that may contribute to viral persistence.

bioRxiv · Feb 12, 2021Immunology