Cell BiologybioRxiv
DHA shortage causes the early degeneration of photoreceptors and RPE in mice with peroxisomal β-oxidation deficiency
D. Swinkels, S. Kocherlakota, Y. Das…·M. Baes
This study shows DHA supplementation rescues early retinal degeneration in Mfp2-/- mice by restoring retinal DHA levels and improving RPE function, but not long-term retinal integrity.
DOI 10.1167/iovs.64.14.10