Author

K. Handler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. E. Moor· 3 shared C. Borrelli· 3 shared A. Lafzi· 2 shared K. Basler· 2 shared T. Valenta· 2 shared A. Gurtner· 1 shared A. Zawistowska-Deniziak· 1 shared B. Becher· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

A. E. Moor

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

In vivo screening of tumor-hepatocyte interactions identifies Plexin B2 as a gatekeeper of liver metastasis

C. Borrelli, M. Roberts, D. Eletto, A. Lafzi, J. A. Kretz, H. Fazilaty, M.-D. Hussherr, E. Guido Vinzoni, K. Handler, J. Michler, S. Adivarahan, S. Piscuoglio, X. Ficht, A. E. Moor

The paper identifies Plexin B2 in hepatocytes as a critical regulator of liver metastasis by promoting epithelial traits in tumor cells through Rac1 signaling.

bioRxiv · May 15, 2023 · PreprintCancer Biology

Single-cell RNA sequencing unveils intestinal eosinophil development and specialization

A. Gurtner, C. Borrelli, N. G. Nunez, I. Gonzalez-Perez, D. Crepaz, K. Handler, T. Valenta, K. Basler, B. Becher, A. E. Moor, I. C. Arnold

The paper uses single-cell transcriptomics and flow cytometry to identify five eosinophil subsets in mice, revealing their developmental stages and specialized functions in the GI tract.

bioRxiv · Oct 27, 2021Immunology

Soluble mannose receptor induces pro-inflammatory macrophage activation and metaflammation

M. Embgenbroich, H. J. van der Zande, L. Hussaarts, J. Schulte-Schrepping, L. R. Pelgrom, N. Garcia-Tardon, L. Schlautmann, I. Stoetzel, K. Handler, J. M. Lambooij, A. Zawistowska-Deniziak, L. Hoving, K. de Ruiter, M. Wijngaarden, H. Pijl, , S. Burgdorf

This study shows that soluble mannose receptor (sMR) promotes pro-inflammatory macrophage activation and metaflammation by inhibiting CD45 phosphatase activity, leading to metabolic dysfunctions in obesity.

bioRxiv · Sep 29, 2020 · PreprintImmunology

Discrete regulation of b-catenin-mediated transcription governs identity of intestinal epithelial stem cells

C. Borrelli, T. Valenta, K. Handler, K. Velez, G. Moro, A. Lafzi, L. de Vargas Roditi, G. Hausmann, A. E. Moor, K. Basler

This study shows that discrete regulation of β-catenin-mediated transcription by co-factors determines the identity and proliferative behavior of intestinal epithelial stem cells.

bioRxiv · May 19, 2020 · PreprintCell Biology