Extensive germline-somatic interplay drives prostate cancer through HNF1B co-option of TMPRSS2-ERG
N. Giannareas, Q. Zhang, X. Yang, Y. Tian, P. Zhang, Y. Yang, A. Manninen, L. Wang, G.-H. Wei
This study identifies HNF1B as a key mediator of prostate cancer risk through its interaction with TMPRSS2-ERG fusion, revealing germline-somatic interplay in disease progression.
bioRxiv · Sep 2, 2021 · PreprintCancer Biology