P. Zhang

Mitochondrial Ca2+ uniporter (MCU) variants form plasma-membrane channels

The paper identifies a novel MCU variant, MCU-S, which forms Ca2+-permeable plasma-membrane channels, expanding the known function of MCU beyond mitochondrial Ca2+ uptake.

In vivo quantification of anterior and posterior chamber volumes in mice: implications for aqueous humor dynamics

This study measures anterior and posterior chamber volumes in mice, finding the anterior chamber constitutes 47% of total aqueous humor volume, significantly different from humans, and suggests previous inflow rate estimates may be overestimated.

Negatively charged α-Synuclein condensate modulates partitioning of molecules

This study shows that negatively charged α-Synuclein condensates influence molecular partitioning based on charge differences, revealing electrostatic effects on phase separation.

Targeting NOTCH2-JAG1 juxtacrine signaling reverses macrophage-mediated tumor resistance to taxol

This study identifies NOTCH2-JAG1 juxtacrine signaling as a target to reverse macrophage-mediated taxane resistance in ovarian cancer by sensitizing tumors to paclitaxel.

Red seaweed supplementation suppresses methanogenesis in the rumen, revealing potentially advantageous traits among hydrogenotrophic bacteria

This study investigates how Asparagopsis supplementation affects rumen microbiota, finding reduced methane production and changes in microbial gene expression and function.

The Fem Cell-surface Signaling System is Regulated by ExsA in Pseudomonas aeruginosa and Affects Pathogenicity

The paper shows that ExsA regulates the Fem system in Pseudomonas aeruginosa, linking it to virulence factors and affecting pathogenicity in vivo.

Right ventricular stiffening and anisotropy alterations in pulmonary hypertension: Mechanisms and relations to function

This study investigates RV biomechanical remodeling in PH, finding that collagen fiber tautness and myofiber reorientation contribute to severe RV dysfunction and failure.

Freeform robotic optical coherence tomography beyond the optical field-of-view limit

This paper introduces a freeform robotic OCT system to overcome the FOV limitation in imaging non-planar anatomies, demonstrating its application in imaging the mouse eye's aqueous humor outflow pathway.

Ancient cyanobacterial proto-circadian clock adapted to short day-night cycles ~ 0.95 billion years ago

The paper reconstructs an ancient cyanobacterial circadian clock from ~0.95 billion years ago and shows it adapts to 18-h day-night cycles but lacks endogenous oscillation.

Deep learning based genomic breeding of pest-resistant grapevine

This study uses deep learning and genome-wide association studies to identify pest-resistant genes in grapevine, achieving high accuracy in predicting pest damage.

Reduction in activity and abundance of mitochondrial electron transport chain supercomplexes in pulmonary hypertension-induced right ventricular dysfunction

This study shows reduced mitochondrial supercomplex activity and abundance in pulmonary hypertension-induced right ventricular dysfunction in rats and humans.

Aroma compounds profile is affected by the initial yeast ratio in wort co-fermentations

This study shows that varying the initial yeast ratio in co-fermentations affects aroma compound production, with a 50/50 ratio producing a balanced profile and a 10/90 ratio generating stronger floral aromas.

PROTAC-mediated dual degradation of BCL-xL and BCL-2 is a highly effective therapeutic strategy in small-cell lung cancer

This paper evaluates a dual BCL-xL/BCL-2 degrader, 753b, showing it effectively reduces tumor viability and growth in SCLC models while avoiding platelet toxicity seen with navitoclax.

Schlafen-11 and -9 are innate immune sensors for intracellular single-stranded DNA

The paper identifies Schlafen-11 and -9 as innate immune sensors that recognize intracellular single-stranded DNA containing CGT motifs, leading to cytokine expression and cell death.

Morroniside promotes skin wound re-epithelialization by facilitating epidermal stem cell proliferation through GLP-1R-mediated upregulation of β-catenin expression

This study shows that morroniside promotes skin wound healing by enhancing epidermal stem cell proliferation through GLP-1R-mediated upregulation of β-catenin and downstream targets.

Using split protein reassembly strategy to control PLD enzymatic activity

This study uses split protein reassembly and optogenetic techniques to control PLD enzymatic activity by modulating domain interactions.

Mannose Supplementation Curbs Liver Steatosis and Fibrosis in Murine MASH by Inhibiting Fructose Metabolism

This study shows that mannose reduces liver steatosis and fibrosis in MASH by inhibiting fructose metabolism, offering a potential therapeutic approach.

Molecular determinants of antagonist interactions with chemokine receptors CCR2 and CCR5

This study identifies molecular determinants of CCR2 and CCR5 antagonist interactions using docking and AI screening, revealing structural principles and selectivity mechanisms.

Systems analysis of long-term heat stress responses in the C4 grass Setaria viridis

This study examines the effects of long-term heat stress on Setaria viridis, revealing changes in metabolism, hormone levels, and gene expression, with a systems model of plant response.

Dynamic gene expression analysis reveals distinct severity phases of immune and cellular dysregulation in COVID-19

This study analyzes longitudinal gene expression in COVID-19 patients to identify distinct disease phases and associated therapeutic targets.

Transport and inhibition mechanism for VMAT2-mediated synaptic loading of monoamines

This study presents cryo-EM structures of VMAT2 bound to substrates and inhibitors, revealing conformational changes and mechanisms of ligand recognition and inhibition.

Genome analysis and hyphal movement characterization of the hitchhiker endohyphal Enterobacter sp. from Rhizoctonia solani

This study characterizes the genome of an endohyphal Enterobacter sp. and describes its hyphal movement and potential ecological impact on fungal hosts.

Structure of Native Chromatin Fibres Revealed by Cryo-ET in situ

This study reveals the 3D structure of native chromatin fibres in human T-lymphoblasts using cryo-ET, showing a relaxed, variable zigzag organization of nucleosomes.

Sirenian genomes illuminate the evolution of fully aquatic species within the mammalian superorder Afrotheria

This study analyzes sirenian genomes to identify genomic adaptations to aquatic life and conservation challenges.

Synergistic activity of rhamnolipid combined with linezolid against linezolid-resistant Enterococcus faecium

This study shows that rhamnolipids combined with linezolid synergistically enhance antibacterial activity against linezolid-resistant Enterococcus faecium through multiple assays and mouse models.

Conservation and divergence of regulatory architecture in nitrate-responsive plant gene circuits

The paper identifies and validates a six-gene regulatory circuit upstream of NLP6/7 in Arabidopsis and tomato, revealing conservation and divergence in nitrogen-responsive gene regulation across species.

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication

This study identifies the role of G3BP1-N interaction in SARS-CoV-2 replication by showing that disrupting this interaction reduces viral replication and pathogenesis.

Identification of a recombinant human astrovirus type 5 strain from an acute gastroenteritis outbreak in Beijing, China

The paper identifies a recombinant human astrovirus type 5 strain from an acute gastroenteritis outbreak in Beijing, China, showing genetic clustering with HAstV-1 and HAstV-5.

Intrinsically disordered CsoS2 acts as a general molecular thread for α-carboxysome shell assembly

The paper investigates the role of intrinsically disordered CsoS2 in α-carboxysome shell assembly using synthetic engineering and cryoEM structures, revealing its function as a molecular thread and identifying a conserved interaction motif.

Molecular architecture and conservation of an immature human endogenous retrovirus

The paper determines the structure of immature HERV-K VLPs using cryoET STA, revealing conserved assembly mechanisms across retroviruses.