BiochemistrybioRxiv
A Universal Allosteric Mechanism for G Protein Activation
K. M. Knight, S. Ghosh, S. L. Campbell…·H. G. Dohlman
This paper identifies a conserved Gly-Arg-Glu motif that mediates G protein subunit dissociation through an allosteric mechanism, and shows that mutations in this motif cause human diseases.
DOI 10.1016/j.molcel.2021.02.002