BioengineeringSmall MethodsPeer-reviewed
Pericytes and Wnt signaling induce functional blood-brain barrier phenotype in human iPSC-based model
Henrique Nogueira Pinto, N. Kok, Philipp Christoph Hauger…·Helga E. de Vries
This paper develops a human iPSC-based model of the blood-brain barrier by co-culturing endothelial cells with pericytes and activating Wnt/β-catenin signaling, resulting in cells with BBB-like properties and gene expression patterns.
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