Phosphodiesterase Type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins.
G. S. Baillie, A. Tibbo, S. Dobi, A. McFall, G. S. Tejeda, C. Blair, R. MacLeod, N. MacQuaide, C. Gok, W. Fuller, B. Smith, G. Smith, T. Brand
The paper shows Popeye domain-containing proteins form complexes with PDE4 phosphodiesterases in cardiac myocytes, restricting cAMP signaling and maintaining action potential duration.
bioRxiv · Sep 10, 2020Biochemistry