G. Smith

Unbiased Population-Based Statistics to Obtain Pathologic Burden of Injury after Experimental TBI

The paper introduces an unbiased whole-brain analysis method to quantify injury burden after traumatic brain injury, showing it is statistically robust and captures longitudinal changes without preselected ROIs.

INCREASED CHLOROPLAST OCCUPANCY IN BUNDLE SHEATH CELLS OF RICE hap3H MUTANTS REVEALED BY CHLORO-COUNT, A NEW DEEP LEARNING-BASED TOOL

The paper develops Chloro-Count, a deep learning tool, to quantify chloroplast occupancy in rice bundle sheath cells and shows that OsHAP3H loss increases chloroplast numbers by 50%.

Alveolar macrophages play a key role in tolerance to ozone

This study identifies alveolar macrophages as critical for ozone tolerance in mice, showing their role in reducing inflammation and injury through suppressed signaling pathways.

Genetic Mapping of Monocyte Fate Decisions Following Myocardial Infarction

The paper maps monocyte differentiation trajectories in the infarcted heart using genetic lineage tracing and single-cell RNA-sequencing, identifying a protective IFN-responsive macrophage subset.

XBB.1.5 Spike Protein COVID-19 Vaccine Induces Broadly Neutralizing and Cellular Immune Responses Against EG.5.1 and Emerging XBB Variants

This study shows that a monovalent XBB.1.5 spike protein vaccine induces broader neutralizing antibodies and stronger cellular immunity against multiple SARS-CoV-2 variants compared to bivalent vaccines.

NVX-CoV2373 ancestral and NVX-CoV2540 BA.5 protein nanoparticle vaccines protect against Omicron BA.5 variant in Syrian hamsters

This study evaluates the efficacy of NVX-CoV2373 and NVX-CoV2540 nanoparticle vaccines against the Omicron BA.5 variant in Syrian hamsters, showing reduced viral infection and better protection compared to mRNA vaccines.

Distinguishing host responses, extensive viral dissemination and long-term viral RNA persistence in domestic sheep experimentally infected with Crimean-Congo hemorrhagic fever virus Kosovo Hoti

This study investigates CCHFV infection in domestic sheep, revealing subclinical infection with viral dissemination and long-term RNA persistence, contrasting with fatal human infections.

A new paradigm of intracrine free fatty acid receptor 4 signaling at lipid droplets

The paper shows FFA4, a GPCR, signals from lipid droplet-associated membranes in adipocytes, providing localized feedback to regulate lipolysis.

GOLDEN2-like1 is sufficient but not necessary for chloroplast biogenesis in mesophyll cells of C4 grasses

The paper shows GLK1 is not required for chloroplast biogenesis in mesophyll cells of C4 grasses, but GLK1 and GLK2 can both restore chloroplast development in mutants of another C4 grass.

Pollen accumulation on hawkmoths varies substantially among moth-pollinated flowers

The study examines pollen accumulation on hawkmoths across different flower species, finding large variation in pollen deposition and loss, influenced by pollen stickiness and visitation frequency.

Diet Induced Obesity and Diabetes Enhance Mortality and Reduces Vaccine Efficacy for SARS-CoV-2

This study shows that obesity and diabetes increase SARS-CoV-2 mortality and reduce vaccine efficacy in mice, with neutrophil depletion improving outcomes.

Nitrate leaching and its implication for Fe and As mobility in a Southeast Asian aquifer

This study investigates how nitrate input affects iron and arsenic mobility in aquifers by examining microbial processes in microcosm experiments.

Control of lipolysis by a population of oxytocinergic sympathetic neurons

This study identifies a population of oxytocinergic sympathetic neurons that regulate adipose tissue lipolysis and metabolic homeostasis in mice and humans.

Highly divergent white-tailed deer SARS-CoV-2 with potential deer-to-human transmission

The paper identifies a highly divergent SARS-CoV-2 lineage in white-tailed deer with evidence of deer-to-human transmission.

Immunogenicity and In vivo protection of a variant nanoparticle vaccine that confers broad protection against emerging SARS-CoV-2 variants

This study evaluates a nanoparticle vaccine against SARS-CoV-2 variants, showing it induces strong immune responses and protection in mice and baboons against multiple variants.

Combination Respiratory Vaccine Containing Recombinant SARS-CoV-2 Spike and QuadrivalentSeasonal Influenza Hemagglutinin Nanoparticles with Matrix-M Adjuvant

This paper evaluates a combination vaccine against seasonal influenza and SARS-CoV-2 in animal models, showing it induces protective immune responses and prevents viral replication and disease.

Collaboration between the Fab and Fc contribute to maximal protection against SARS-CoV-2 in nonhuman primates following NVX-CoV2373 subunit vaccine with Matrix-M™ vaccination

This study shows that NVX-CoV2373 vaccine induces antibodies with both neutralizing and Fc-effector functions, which together provide maximal protection against SARS-CoV-2 in non-human primates.

SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral Spike vaccines

This study shows that B.1.1.7 SARS-CoV-2 variant remains neutralizable by antibodies from ancestral Spike vaccines and convalescent sera, though with reduced efficacy.

Flexible RSV prefusogenic fusion glycoprotein exposes multiple neutralizing epitopes that may collectively contribute to protective immunity

This study compares the immunogenicity of native prefusogenic RSV F glycoprotein variants in animal models, finding that native F elicits broader neutralizing antibodies targeting multiple epitopes compared to variants with structural modifications.

Susceptibility of domestic swine to experimental infection with SARS-CoV-2

This study shows that domestic pigs can be infected with SARS-CoV-2, with viral RNA and antibodies detected, highlighting the need for further livestock assessment in pandemic risk management.

Phosphodiesterase Type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins.

The paper shows Popeye domain-containing proteins form complexes with PDE4 phosphodiesterases in cardiac myocytes, restricting cAMP signaling and maintaining action potential duration.

Amino acids whose intracellular levels change most during aging alter chronological lifespan of fission yeast

The paper identifies amino acids whose intracellular levels change with aging in fission yeast and shows their impact on chronological lifespan.

NVX-CoV2373 vaccine protects cynomolgus macaque upper and lower airways against SARS-CoV-2 challenge

This study evaluates the NVX-CoV2373 vaccine in cynomolgus macaques, showing it induces neutralizing antibodies and protects against SARS-CoV-2 infection in upper and lower airways.

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

The paper uses cryo-EM and glycan analysis to study the structure of a full-length SARS-CoV-2 spike protein in a vaccine candidate, revealing its stable prefusion conformation and novel trimer interactions.

Decadal changes in fire frequencies shift tree communities and functional traits

This study shows that long-term changes in fire frequency alter tree communities and functional traits across different ecosystems.

SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 elicits immunogenicity in baboons and protection in mice

This study evaluates the immunogenicity and protective efficacy of the NVX-CoV2373 SARS-CoV-2 vaccine in baboons and mice, showing strong immune responses and protection without enhanced disease.

Ozone-induced changes in murine lung extracellular vesicle number and small RNA content

This study shows ozone exposure increases extracellular vesicle numbers and alters miRNA content in mouse lung BALF, with potential regulatory roles for specific miRNAs in airway macrophage responses.

Discovery of a 382-nt deletion during the early evolution of SARS-CoV-2

The paper identifies a 382-nt deletion in SARS-CoV-2 ORF8 from Singapore patients, which enhances N gene transcription and may contribute to viral attenuation.

A precision virtual crossmatch decision support system for interpretation of ambiguous molecular HLA typing data

The paper develops a tool to assist in virtual crossmatch decisions by analyzing ambiguous HLA typing data and shows it can influence transplant offer evaluations.

Assessing metadata and curation quality: a case study from the development of a third-party curation service at Springer Nature

The paper describes a project to assess metadata quality during the development of a third-party curation service for research data.