Phosphorylation of the M1 muscarinic acetylcholine receptor mediates protection in neurodegenerative disease
M. Scarpa, C. Molloy, L. Jenkins…·S. J. Bradley
This study shows that phosphorylation and arrestin-dependent signaling of the M1 muscarinic receptor provides neuroprotection in prion disease, suggesting potential for developing safer therapies for neurodegenerative diseases.