Aberrant Ca2+ homeostasis in adipocytes links inflammation to metabolic dysregulation in obesity
E. Guney, A. P. Arruda, G. Parlakgul, E. Cagampan, N. Min, Y. Lee, L. Greene, E. Tsaousidou, K. Inouye, M. S. Han, R. J. Davis, G. S. Hotamisligil
This study identifies IP3R over-activation in adipocytes as a key mechanism linking obesity, inflammation, and insulin resistance, suggesting therapeutic targeting of Ca2+ homeostasis.
bioRxiv · Oct 28, 2020Physiology