Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease
E. Urbauer, D. Aguanno, N. Mindermann, H. Omer, A. Metwaly, T. Krammel, T. Faro, M. Remke, S. Reitmeier, S. Bärthel, J. Kersting, Z. Huang, F. Xian, M. Schmidt, D. Saur, , D. Haller
The paper shows mitochondrial dysfunction in intestinal epithelium leads to microbiota-dependent injury and identifies gene signatures that distinguish active from inactive inflammation in IBD.
bioRxiv · Jul 27, 2023 · PreprintMicrobiology