D. Saur

Mitochondrial perturbation in the intestine causes microbiota-dependent injury and gene signatures discriminative of inflammatory disease

The paper shows mitochondrial dysfunction in intestinal epithelium leads to microbiota-dependent injury and identifies gene signatures that distinguish active from inactive inflammation in IBD.

The pharmacoepigenomic landscape of cancer cell lines reveals the epigenetic component of drug sensitivity

The paper identifies DNA methylation biomarkers linked to drug sensitivity in cancer cell lines across multiple cancer types and drugs.

ZEB1-dependent modulation of fibroblast polarization governs inflammation and immune checkpoint blockade sensitivity in colorectal cancer

This study shows that ZEB1 in cancer-associated fibroblasts suppresses anti-tumor immunity and promotes metastasis, and its loss increases immune checkpoint sensitivity.

Stromal HIF2 Regulates Immune Suppression in the Pancreatic Cancer Microenvironment

This study shows that deleting HIF2 in cancer-associated fibroblasts reduces pancreatic tumor growth and immunosuppression, suggesting HIF2 as a therapeutic target.

A GATA6-centered gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer

This paper identifies a GATA6-centered gene regulatory network involving HNFs and ΔNp63 that controls plasticity and immune escape in pancreatic cancer, showing GATA6 loss is necessary but not sufficient for the basal phenotype.

ExoBow: A transgenic strategy to study CD63 exosomes in vivo

The paper introduces ExoBow, a transgenic mouse model that enables tracking of CD63+ exosomes in vivo to study inter- and intra-organ communication.

Pancreatic Cancer Intrinsic PI3Kα Activity accelerates Metastasis and rewires Macrophage Component

This paper identifies PI3K pathway activation as a driver of metastatic progression in pancreatic cancer and shows that targeting PI3K can delay macro-metastatic evolution.

Porcine model elucidates function of p53 isoform in carcinogenesis

This study uses a porcine model to show that specific p53 isoforms and circular TP53 RNA drive tumorigenesis, particularly osteosarcoma, in pigs and likely have similar roles in humans.

Targeting the ubiquitin-proteasome system in a pancreatic cancer subtype with hyperactive MYC

The paper identifies bortezomib as a potential therapy for MYC hyperactive pancreatic cancer by showing its sensitivity to proteasome inhibition.