BiochemistrybioRxiv
Small Molecule Targeting IRES Domain Inhibits Enterovirus 71 Replication via an Allosteric Mechanism that Stabilizes a Ternary Complex
J. Davila-Calderon, N. N. Patwardhan, L.-Y. Chiu…·B. S. Tolbert
The paper identifies a small molecule that inhibits EV71 replication by stabilizing a ternary complex with RNA and AUF1 protein via an allosteric mechanism.
DOI 10.1038/s41467-020-18594-3