Evidence that conserved essential genes are enriched for pro-longevity factors
N. Oz, E. Vayndorf, M. Tsuchiya, S. McLean, L. Turcios-Hernandez, J. N. Pitt, B. W. Blue, M. Muir, M. G. Kiflezghi, A. Tyshkovskiy, A. Mendenhall, M. Kaeberlein, A. Kaya
The paper shows that overexpressing conserved essential genes in yeast increases replicative lifespan more than deleting them, suggesting essential genes are important for longevity.
bioRxiv · Mar 18, 2022Cell Biology