M. Muir

Evidence that conserved essential genes are enriched for pro-longevity factors

The paper shows that overexpressing conserved essential genes in yeast increases replicative lifespan more than deleting them, suggesting essential genes are important for longevity.

Loss of the adhesion protein Kindlin-1 stimulates tumor clearance via modulation of Tregs

This study shows that loss of Kindlin-1 in breast cancer cells reduces tumor growth by decreasing Treg numbers and function, mediated by increased IL-6 secretion.

Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors.

This study profiles the effects of the SRC inhibitor AZD0424 in combination with MEK inhibitors, showing reduced compensatory activation and enhanced anti-tumor effects in colorectal cancer models.

11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis

This study investigates the effect of 11β-HSD1 inhibition on tumour growth and angiogenesis in murine models, finding increased SCC tumour growth but no effect on angiogenesis.

Toll-like receptor 2 orchestrates a potent anti-tumor response in non-small cell lung cancer

This study identifies TLR2 as a tumor suppressor in early-stage lung cancer, showing its role in immune surveillance and tumor growth reduction through synthetic agonist administration.

Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence.

This study shows that caspase-4 non-canonical inflammasome activation by LPS induces cellular senescence and contributes to oncogene-induced senescence and tumour suppression.

ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling

This study shows that ISGylation promotes breast tumour progression by enhancing EGFR recycling and Akt signalling, acting as a driver rather than just a marker of cancer.

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype.

This study identifies TLR2 as a key mediator of oncogene-induced senescence by promoting cell cycle arrest and regulating the senescence-associated secretory phenotype through DAMPs.

A Synergistic Anti-Cancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High Content Phenotypic Screen

The paper identifies a synergistic combination of FAK and HDAC inhibitors using a chemical-genetic high-content screen, showing efficacy in cancer cell lines and in vivo.