Naive arthritogenic SKG T cells have a defect in anergy and a repertoire pruned by superantigen
J. F. Ashouri, E. McCarthy, S. Yu, N. Perlmutter, C. Lin, J. DeRisi, C. J. Ye, A. Weiss
This study identifies a defect in anergy and a biased TCR repertoire in naive arthritogenic SKG CD4 T cells, driven by endogenous viral superantigens, leading to autoimmune arthritis.
bioRxiv · Jan 13, 2022 · PreprintImmunology