Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli are Altered with Age
M. Mann, A. Mehta, C. de Boer, M. S. Kowalczyk, K. Lee, N. Rogel, A. R. Knecht, D. Farouq, A. Regev, D. Baltimore
The paper shows that aged hematopoietic stem cells exhibit a myeloid-biased transcriptional response to inflammation, which is linked to Klf5, Ikzf1, and Stat3.
bioRxiv · Nov 14, 2017Immunology