Author

D. Baltimore

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. R. Heath· 2 shared A. H. Ng· 1 shared A. M. Xu· 1 shared A. Mehta· 1 shared A. R. Knecht· 1 shared A. Regev· 1 shared A. Ribas· 1 shared A. V. Joglekar· 1 shared

Activity by Year

2017-2019 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBioengineering

J. R. Heath

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Author profile →

5 papers

Recent·Most cited

Sequence-Dependent Dynamics of Synthetic and Endogenous RSSs in V(D)J Recombination

S. Hirokawa, G. Chure, N. M. Belliveau, G. A. Lovely, M. Anaya, D. G. Schatz, D. Baltimore, R. Phillips

The paper quantifies sequence-dependent dynamics of RAG-RSS interactions in V(D)J recombination, revealing how single-bp changes affect PC formation, stability, and cleavage.

bioRxiv · Oct 4, 2019Immunology

Trajectories from Snapshots: Integrated proteomic and metabolic single-cell assays reveal multiple independent adaptive responses to drug tolerance in a BRAF-mutant melanoma cell line

Y. Su, G. Li, M. E. Ko, H. Cheng, R. Zhu, M. Xue, J. Wang, J. W. Lee, L. Frankiw, A. Xu, S. Wong, L. Robert, K. Takata, S. Huang, A. Ribas, , J. R. Heath

The paper uses integrated proteomic and metabolic single-cell assays to identify two distinct adaptive pathways in BRAF-mutant melanoma cells during drug treatment.

bioRxiv · Sep 12, 2019 · PreprintBioengineering

MATE-Seq: Microfluidic Antigen-TCR Engagement Sequencing

A. H. Ng, S. Peng, A. M. Xu, W. J. Noh, K. Guo, M. T. Bethune, W. Chour, J. Choi, S. Yang, D. Baltimore, J. R. Heath

MATE-Seq identifies antigen-specific T-cell receptors by isolating and sequencing T-cells bound to peptide-MHC tetramers with high sensitivity.

bioRxiv · Jul 18, 2019Immunology

T Cell Receptor Immunotherapy Drives Human Immunodeficiency Virus Evolution in Humanized Mice

A. V. Joglekar, M. Swift, M. T. Leonard, J. D. Jeppson, S. Sandoval, D. Baltimore

This study shows that TCR immunotherapy suppresses HIV in humanized mice but drives viral evolution under selection pressure.

bioRxiv · Mar 12, 2019 · PreprintImmunology

Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli are Altered with Age

M. Mann, A. Mehta, C. de Boer, M. S. Kowalczyk, K. Lee, N. Rogel, A. R. Knecht, D. Farouq, A. Regev, D. Baltimore

The paper shows that aged hematopoietic stem cells exhibit a myeloid-biased transcriptional response to inflammation, which is linked to Klf5, Ikzf1, and Stat3.

bioRxiv · Nov 14, 2017Immunology