Expansion of human hematopoietic stem cells by inhibiting translation
C. Li, H. Shin, D. Bhavanasi, M. Liu, X. Yu, X. Liu, F. Herbst-Nowrouzi, M.-G. Alameh, L. Breda, N. Kovuru, Y. Kwa, N. Sam, S. Rivella, J. R. Alvarez--Dominguez, G. A. Blobel, , P. S. Klein
This paper identifies translation inhibitors that enable ex vivo expansion of human hematopoietic stem cells from umbilical cord blood while maintaining their function and enabling gene editing.
bioRxiv · Nov 28, 2023 · PreprintCell Biology