H. Shin

Expansion of human hematopoietic stem cells by inhibiting translation

This paper identifies translation inhibitors that enable ex vivo expansion of human hematopoietic stem cells from umbilical cord blood while maintaining their function and enabling gene editing.

Spin-coupled electron densities of iron-sulfur cluster imaged by in situ serial Laue diffraction

The paper uses in situ serial Laue diffraction to image spin-coupled electron densities in a [4Fe4S] iron-sulfur cluster during light-induced redox reactions.

Endogenous circadian reporter cell lines as an efficient platform for studying circadian mechanisms

The paper develops Per1-luc and Per2-luc reporter cell lines to study circadian mechanisms and uncover differences between Per and Cry paralogs.

A merger between compatible but divergent genomes supports allopolyploidization in the Brassicaceae family

This study investigates how genome divergence and compatibility contribute to the stabilization of hybrid genomes in an allopolyploid plant species.

A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection

This study identifies a type I IFN-neutrophil-IL-18 axis driving immunopathology in genital HSV-2 infection.

Human spinal cord organoids exhibiting neural tube morphogenesis for a quantifiable drug screening system of neural tube defects

This study develops human spinal cord-like organoids (hSCOs) to enable quantitative drug screening for neural tube defects.

Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice

The paper introduces iSLET, a method to track tissue-specific secretory proteins in live mice, demonstrating its use in labeling and identifying liver-specific secreted proteomes in blood plasma.

Antiviral activity of lambda-carrageenan against influenza viruses in mice and severe acute respiratory syndrome coronavirus 2 in vitro

This study evaluates lambda-carrageenan's antiviral effects against influenza and SARS-CoV-2, showing dose-dependent inhibition and protective effects in mice.

Entelon(R) (vitis vinifera seed extract) reduces inflammation and calcification in a beagle dog model of intravascular bovine pericardium implantation

This study evaluates the anti-inflammatory and anti-calcification effects of Entelon150(R) in a beagle dog model of bovine pericardium implantation, finding reduced calcium content and inflammation.

Molecular Basis of Far-red Sensing in Cyanobacteriochrome

This study reports the crystal structure of a far-red-sensing cyanobacteriochrome and identifies key protein-chromophore interactions that enable far-red light perception.

Targeting the oncogene LSF with either the small molecule inhibitor FQI1 or siRNA causes mitotic delays with unaligned chromosomes, resulting in cell death or senescence

This study shows that inhibiting LSF with FQI1 or siRNA causes mitotic delays and cell death in HeLa cells, supporting LSF as a cancer therapeutic target.

Dynamics of Notch-dependent transcriptional bursting in its native context

This study examines how Notch signaling regulates transcriptional bursting in C. elegans germline stem cells, finding that Notch modulates burst duration rather than intensity or OFF-time.