Single-Cell Multiomics Defines Tolerogenic Extrathymic Aire-Expressing Populations with Unique Homology to Thymic Epithelium
J. Wang, C. A. Lareau, J. L. Bautista, A. R. Gupta, K. Sandor, J. Germino, Y. Yin, M. P. Arvedson, G. C. Reeder, N. T. Cramer, F. Xie, V. Ntranos, A. T. Satpathy, M. S. Anderson, J. M. Gardner
This paper identifies two extrathymic Aire-expressing cell types with transcriptional and genomic similarities to thymic epithelium and shows their role in immune tolerance.
bioRxiv · Nov 5, 2021Immunology