F. Xie

Biochemical characterization of extended-spectrum β-lactamases from Akkermansia genus

The paper characterizes β-lactamases from Akkermansia species, showing they exhibit extended-spectrum activity and lack transferable resistance genes.

RinRK1 Promotes Accumulation of Nod Factor Receptors in Nanodomain-like structures at the tip of infected root hairs

This study identifies RinRK1's role in localizing Nod Factor Receptors to root hair tips through interactions with Flotillin 1, facilitating symbiotic infection.

Robust Neutralization of SARS-CoV-2 Variants Including JN.1 and BA.2.87.1 by Trivalent XBB Vaccine-Induced Antibodies

The paper compares antibody responses from individuals with XBB reinfection and those vaccinated with WSK-V102C, showing the vaccine induces stronger neutralization against SARS-CoV-2 variants including JN.1 and BA.2.87.1.

Enhanced neutralization of SARS-CoV-2 XBB sub-lineages and BA.2.86 by a tetravalent COVID-19 vaccine booster

This study evaluates the neutralization efficacy of a tetravalent vaccine booster against emerging SARS-CoV-2 variants, finding it induces higher neutralizing titers than breakthrough infection.

A novel architecture of PT neuron-based corticothalamic connectivity in the auditory system

The paper reveals a fully-connected corticothalamic architecture in the auditory system, showing L5 neurons project broadly to thalamic modules, challenging traditional hierarchical models.

Atlas-Guided Discovery of Transcription Factors for T Cell Programming

The paper identifies transcription factors driving distinct CD8+ T cell states and shows their impact on tumor control and immunotherapy.

Insights into the biosynthesis of icumazole unveiling a distinctive family of crotonyl-CoA carboxylase/reductase

The paper identifies a novel family of crotonyl-CoA carboxylase/reductase (CCR) enzymes involved in icumazole biosynthesis, revealing unique substrate specificity and cofactor usage.

RPG interacts with E3-ligase CERBERUS to mediate rhizobial infection in Lotus japonicus

The paper identifies RPG as required for infection thread formation in Lotus japonicus and shows it interacts with CERBERUS to mediate polarity growth driven by nuclear migration.

Hepatic AMPK activation in response to dynamic REDOX balance is a biomarker of exercise to improve blood glucose control

The paper compares exercise and antioxidant intervention in type 2 diabetic rats, showing both improve blood glucose via hepatic AMPK activation and redox balance, with exercise promoting moderate ROS for AMPK activation.

Polo-like kinase-1 Inhibitors and the Antiandrogen Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling

This study shows that combining Plk1 inhibitors with abiraterone synergistically kills cancer cells across tumor types, independent of androgen receptor signaling, through mitotic disruption.

Profiling the size-dependent heterogeneity of membrane proteins in a mixed population of small extracellular vesicle for potential cancer diagnosis

This study profiles size-dependent membrane protein heterogeneity in small EVs to improve cancer diagnosis accuracy using a novel single EV enumeration approach.

Single-Cell Multiomics Defines Tolerogenic Extrathymic Aire-Expressing Populations with Unique Homology to Thymic Epithelium

This paper identifies two extrathymic Aire-expressing cell types with transcriptional and genomic similarities to thymic epithelium and shows their role in immune tolerance.

Principles of ecDNA random inheritance drive rapid genome change and therapy resistance in human cancers

Inhibition of aryl hydrocarbon receptor signaling promotes the terminal differentiation of human erythrocytes

This study shows that inhibiting AHR signaling enhances terminal differentiation of human erythrocytes by promoting F-actin remodeling and cytoskeleton maturation.

GPI anchor remodeling by the plant PGAP1 ortholog HLD1 is essential for Papaver self-incompatibility

The study identifies HLD1, an ortholog of PGAP1, as essential for Papaver self-incompatibility through GPI-anchor remodeling.

Hydroxyl-radical scavenging activity of hydrogen does not significantly contribute to its biological function

This study challenges the idea that hydrogen's antioxidant properties are its main biological function by showing limited hydroxyl radical scavenging and suggesting alternative mechanisms.

TRAF4 inhibits bladder cancer progression by promoting BMP/SMAD signalling pathway

This study identifies TRAF4 as a tumor suppressor in bladder cancer that promotes BMP/SMAD signaling and inhibits metastasis by targeting SMURF1 for degradation.

Heart Rate n-Variability (HRnV) and Its Application to Risk Stratification of Chest Pain Patients in the Emergency Department

This study introduces HRnV, a new measure of heart rate variability, and shows it improves risk prediction for adverse cardiac events in chest pain ED patients compared to traditional scores.

Exploring spatiotemporal changes in ecosystem service values and hotspots in Southwest of China, Mekong Region

This paper assesses spatiotemporal changes in ecosystem service values in Xishuangbanna over two decades using remote sensing data and ecological economics theories.

Hydrogen evolution and absorption phenomena in plasma membrane of higher plants

The paper detects hydrogen evolution and absorption in plasma membrane vesicles of higher plants using spectrophotometry, gas chromatography, and H2 sensors, revealing bidirectional H2 activity.

Bidirectional Control of Coronary Vascular Resistance by Eicosanoids via a Novel GPCR

The paper identifies GPR39 as a microvascular smooth muscle cell receptor regulated by opposing eicosanoids, 15-HETE and 14,15-EET, which modulate coronary vascular resistance through distinct mechanisms.