Author

N. Thapa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

M. Chen· 2 shared R. A. Anderson· 2 shared V. L. Cryns· 2 shared C. Chen· 1 shared S. Choi· 1 shared T. Wen· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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2 shared papersCell Biology

M. Chen

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2 papers

Recent·Most cited

Enhanced PI3K/Akt Signaling in Response to p85α Loss is Regulated by Endosomal PI3Kα and PI3P

N. Thapa, M. Chen, V. L. Cryns, R. A. Anderson

This study shows that p85 loss enhances PI3K/Akt signaling through endosomal p110 activation via MAP4 and PI3P binding.

bioRxiv · Jan 10, 2024 · PreprintCell Biology

A p53-Phosphoinositide Signalosome Regulates Nuclear Akt Activation

M. Chen, S. Choi, T. Wen, C. Chen, N. Thapa, V. L. Cryns, R. A. Anderson

The paper shows p53 forms a nuclear PI3K-Akt pathway that activates Akt independently of the canonical membrane pathway, with implications for cancer therapy.

bioRxiv · Sep 17, 2021Cell Biology