Author

T. Wen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2 Cell Biology· 2 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 5 Research Focus:cancer & tumor microenvironment· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 2 Assay:cryo-EM· 2 Approach:mechanistic / dynamical model· 2 Organism:mouse· 2

Frequent Co-Authors

M. Chen· 3 shared R. A. Anderson· 3 shared V. L. Cryns· 3 shared Y. Li· 3 shared C. Chen· 2 shared N. D. Carrillo· 2 shared P. Awasthi· 2 shared S. Chang· 2 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

M. Chen

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Regulation of NRF2 by Phosphoinositides and Small Heat Shock Proteins

C. Chen, M. Chen, T. Wen, P. Awasthi, N. D. Carrillo, R. A. Anderson, V. L. Cryns

This study shows that PIPKIγ and HSP27 regulate NRF2 stability and function, promoting stress resistance and suggesting them as potential drug targets in cancer.

bioRxiv · Oct 26, 2023 · PreprintCancer Biology

Lipid Transfer Proteins and PI4KIIα Initiate Nuclear p53-Phosphoinositide Signaling

N. D. Carrillo, M. Chen, T. Wen, P. Awasthi, C. Sterling, D. Brahmbhatt, V. L. Cryns, R. A. Anderson

The paper identifies PITP/β and PI4KIIα as key regulators initiating nuclear p53-PIPn signaling through PI transfer and phosphorylation, with implications for cancer therapy.

bioRxiv · May 8, 2023Cell Biology

VPS9D1-AS1 overexpression amplifies intratumoral TGF-β signaling and promotes tumor cell escape from CD8+ T cell killing in colorectal cancer

L. Yang, X. Dong, Z. Liu, X. Huang, J. Tan, T. Wen, H. Qu, Z. Wang

This study identifies VPS9D1-AS1 as a lncRNA that enhances TGF-β signaling and immune evasion in colorectal cancer by modulating translation and ISG expression.

bioRxiv · May 12, 2022Cancer Biology

Pancreatic Tumor Eradication via Selective PIN1 Inhibition in Cancer Associated Fibroblasts and T Lymphocytes Engagement

J. Liu, T. Wen, Z. Li, Y. Liu

This study demonstrates that selective PIN1 inhibition in CAFs and engagement of T lymphocytes using a bispecific system effectively eradicates pancreatic tumors in mice.

bioRxiv · Jan 31, 2022Bioengineering

Targeting of Cdc42 GTPase in regulatory T cells unleashes anti-tumor T cell immunity

K. W. Kalim, J.-Q. Yang, M. Wunderlich, V. Modur, P. Nguyen, Y. Li, T. Wen, A. Kuenzi, R. Verma, Q. R. Lu, A. G. Jegga, Y. Zheng, F. Guo

This study shows that targeting Cdc42 in regulatory T cells promotes anti-tumor immunity without causing autoimmunity by inducing Treg plasticity and altering pH through carbonic anhydrase I.

bioRxiv · Sep 23, 2021 · PreprintImmunology

A p53-Phosphoinositide Signalosome Regulates Nuclear Akt Activation

M. Chen, S. Choi, T. Wen, C. Chen, N. Thapa, V. L. Cryns, R. A. Anderson

The paper shows p53 forms a nuclear PI3K-Akt pathway that activates Akt independently of the canonical membrane pathway, with implications for cancer therapy.

bioRxiv · Sep 17, 2021Cell Biology

Cryo-EM structure of the human TACAN channel in a closed state

x. chen, Y. Wang, Y. Li, X. Lu, j. chen, M. Li, T. Wen, n. liu, S. Chang, X. Zhang, X. Yang, Y. Shen

The paper presents the cryo-EM structure of the human TACAN channel in a closed state and identifies key residues and cholesterol interactions involved in its function.

bioRxiv · Aug 23, 2021 · PreprintBiochemistry

Dynamic assembly of the calcium hemostasis modulator 1 channel gates ATP permeation

Y. Ren, Y. Li, Y. Wang, T. Wen, X. Lu, S. Chang, X. Zhang, Y. Shen, X. Yang

This study reports cryo-EM structures of CALHM1 channels and proposes a mechanism for ATP permeation through dynamic N-helix movement.

bioRxiv · Jan 14, 2021 · PreprintBiochemistry