V. L. Cryns

Enhanced PI3K/Akt Signaling in Response to p85α Loss is Regulated by Endosomal PI3Kα and PI3P

This study shows that p85 loss enhances PI3K/Akt signaling through endosomal p110 activation via MAP4 and PI3P binding.

Heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue

This study shows that heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue by affecting UCP1 and mitochondrial function.

Regulation of NRF2 by Phosphoinositides and Small Heat Shock Proteins

This study shows that PIPKIγ and HSP27 regulate NRF2 stability and function, promoting stress resistance and suggesting them as potential drug targets in cancer.

Lipid Transfer Proteins and PI4KIIα Initiate Nuclear p53-Phosphoinositide Signaling

The paper identifies PITP/β and PI4KIIα as key regulators initiating nuclear p53-PIPn signaling through PI transfer and phosphorylation, with implications for cancer therapy.

A p53-Phosphoinositide Signalosome Regulates Nuclear Akt Activation

The paper shows p53 forms a nuclear PI3K-Akt pathway that activates Akt independently of the canonical membrane pathway, with implications for cancer therapy.

Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence

The paper shows that SAM depletion leads to adaptive chromatin changes that maintain heterochromatin stability and epigenetic persistence in mice.