Cancer BiologybioRxivPreprint
A neural crest stem cell-like state drives nongenetic resistance to targeted therapy in melanoma
O. Marin-Bejar, A. Rogiers, M. Dewaele…·J.-C. Marine
This study identifies a neural crest stem cell-like state in melanoma minimal residual disease that drives nongenetic resistance to MAPK-targeted therapy and shows that targeting FAK/SRC signaling can delay relapse.
DOI 10.1101/2020.12.15.422929