BiochemistrybioRxiv
Signal peptide mimicry primes Sec61 for client-selective inhibition
S. Rehan, D. Tranter, P. P. Sharp…·V. Paavilainen
This study describes KZR-8445, a cyclic depsipeptide that selectively inhibits Sec61-mediated protein biogenesis by mimicking signal peptides, showing efficacy in a rheumatoid arthritis model.
DOI 10.1038/s41589-023-01326-1