Author

D. Tranter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

M. Javanainen· 3 shared V. Paavilainen· 3 shared J. T. Huiskonen· 2 shared S. Karki· 2 shared S. Rehan· 2 shared A. Jennings· 1 shared C. Bulawa· 1 shared C. J. Kirk· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBiochemistry

M. Javanainen

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The Sec61/TRAP Translocon Scrambles Lipids

M. Javanainen, S. Karki, D. Tranter, D. Biriukov, V. O. Paavilainen

The paper investigates the lipid scrambling activity of Sec61 and TRAP using molecular dynamics simulations, showing they facilitate lipid flip-flop via a credit card mechanism and are selective for phosphatidylcholine.

bioRxiv · Nov 23, 2023 · PreprintBiophysics

Molecular view of ER membrane remodeling by the Sec61/TRAP translocon

S. Karki, M. Javanainen, D. Tranter, S. Rehan, J. T. Huiskonen, L. Happonen, V. Paavilainen

The paper determines the structure of the Sec61/TRAP complex bound to a ribosome using Cryo-EM, revealing how TRAP facilitates ER membrane remodeling and polypeptide translocation.

bioRxiv · Sep 30, 2022Biochemistry

Signal peptide mimicry primes Sec61 for client-selective inhibition

S. Rehan, D. Tranter, P. P. Sharp, E. Lowe, J. Anderl, T. Muchamuel, V. Abrishami, S. Kuivanen, N. Wenzell, A. Jennings, C. Kalyanaraman, G. B. Craven, T. Strandin, M. Javanainen, O. Vapalahti, , V. Paavilainen

This study describes KZR-8445, a cyclic depsipeptide that selectively inhibits Sec61-mediated protein biogenesis by mimicking signal peptides, showing efficacy in a rheumatoid arthritis model.

bioRxiv · Jul 3, 2022Biochemistry

Snapshots of actin and tubulin folding inside the TRiC chaperonin

J. J. Kelly, D. Tranter, E. Pardon, G. Chi, H. Kramer, K. Knee, J. Janz, J. Steyaert, C. Bulawa, V. Paavilainen, J. Huiskonen, W. Yue

The paper captures structural snapshots of actin and tubulin folding within the TRiC chaperonin using cryo-EM, revealing how substrates interact with the chamber during folding.

bioRxiv · Mar 26, 2021Biochemistry