Author

E. Lowe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Jennings· 1 shared B. Akiyoshi· 1 shared B. Guloglu· 1 shared C. J. Kirk· 1 shared C. Kalyanaraman· 1 shared C. Kleanthous· 1 shared C. M. A. Thompson· 1 shared C. Redfield· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperBiochemistry

A. Jennings

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural basis for DARC binding in reticulocyte invasion by Plasmodium vivax

R. Moskovitz, T. Pholcharee, S. DonVito, B. Guloglu, E. Lowe, F. Mohring, R. W. Moon, M. K. Higgins

The paper determines the structure of PvDBP-RII bound to sulphated DARC peptide, identifies a critical sulphate interaction, and reveals an epitope for a growth-inhibitory antibody.

bioRxiv · Feb 28, 2023 · PreprintMicrobiology

Signal peptide mimicry primes Sec61 for client-selective inhibition

S. Rehan, D. Tranter, P. P. Sharp, E. Lowe, J. Anderl, T. Muchamuel, V. Abrishami, S. Kuivanen, N. Wenzell, A. Jennings, C. Kalyanaraman, G. B. Craven, T. Strandin, M. Javanainen, O. Vapalahti, , V. Paavilainen

This study describes KZR-8445, a cyclic depsipeptide that selectively inhibits Sec61-mediated protein biogenesis by mimicking signal peptides, showing efficacy in a rheumatoid arthritis model.

bioRxiv · Jul 3, 2022Biochemistry

Structural characterisation of KKT4, an unconventional microtubule-binding kinetochore protein

P. Ludzia, E. Lowe, G. Marciano, S. Mohammed, C. Redfield, B. Akiyoshi

This study characterizes the structure and dynamics of KKT4, a kinetoplastid kinetochore protein, revealing its microtubule-binding domain and DNA-binding properties.

bioRxiv · Oct 14, 2020Cell Biology

Pyocin S5 import into Pseudomonas aeruginosa reveals a generic mode of bacteriocin transport

H. M. Behrens, E. Lowe, J. Gault, N. G. Housden, R. Kaminska, T. M. Weber, C. M. A. Thompson, G. L. A. Mislin, I. Schalk, D. Walker, C. V. Robinson, C. Kleanthous

The paper identifies the import mechanism of Pyocin S5 in Pseudomonas aeruginosa, revealing a generic pathway for TonB-dependent bacteriocins across Gram-negative bacteria.

bioRxiv · Nov 26, 2019Biochemistry