Cancer BiologybioRxivPreprint
Metabolic plasticity enables cancer adaptation to acidic tumor ecosystems
Raafat Chalar, Naheel Khatri, Jowana Obeid…·Mehdi Damaghi
This study shows cancer cells adapt to acidic tumor environments through sphingolipid metabolic plasticity, revealing that targeting metabolic flexibility, not individual pathways, may be more effective.
DOI 10.64898/2026.01.14.699600