NeuroscienceOpen BiologyPeer-reviewed
The structure of an Amyloid Precursor Protein/talin complex indicates a mechanical basis of Alzheimer's Disease.
Charles Ellis, Natasha L. Ward, Matthew Rice…·Benjamin Thomas Goult
This paper presents the crystal structure of an APP/talin complex, proposing APP processing as a mechanical signalling pathway involved in synaptic homeostasis and suggesting a new hypothesis for Alzheimer's disease.
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