Karyotypic divergence confounds cellular phenotypes in large pharmacogenomic studies
Rene Quevedo, Nehme El-Hachem, Petr Smirnov…·Benjamin Haibe-Kains
This study identifies discordances in genotypic and karyotypic profiles across pharmacogenomic datasets, highlighting the impact of copy-number variants on drug response and the need for verification of cell line profiles.