Author

Nicholas A. Sambold

Arc Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Caroline M. WilsoniD· 2 shared Luke A. GilbertiD· 2 shared Abolfazl ArabiD· 1 shared Chris C.‐S. HsiungiD· 1 shared Daniel D. RichmaniD· 1 shared Greg C. PommieriD· 1 shared Jeffrey A. HussmanniD· 1 shared Jonathan S. WeissmaniD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersSynthetic Biology

Caroline M. WilsonORCID

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2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintOct 28, 2024

Combinatorial effector targeting (COMET) for transcriptional modulation and locus-specific biochemistry

Caroline M. Wilson, Greg C. Pommier, Daniel D. Richman…·Luke A. Gilbert

The paper introduces COMET, a high-throughput screening platform for identifying transcriptional modulators by testing combinatorial dCas9-based fusion proteins, and finds over 5800 significant hits that modulate transcription.

6 citations

humanCRISPR screen

𝕏 PostBluesky

GeneticsNature BiotechnologyPeer-reviewedMay 17, 2024

Higher-order combinatorial chromatin perturbations by engineered CRISPR-Cas12a for functional genomics

Chris C.‐S. Hsiung, Caroline M. Wilson, Nicholas A. Sambold…·Luke A. Gilbert

The paper introduces multiAsCas12a, an engineered CRISPR-Cas12a variant enabling higher-order combinatorial chromatin perturbations, and demonstrates its use in discovering new enhancer elements and dissecting cis-regulatory element functions.

53 citationstop 1%

CRISPR screenexperimental assay

𝕏 PostBluesky