NeurosciencebioRxivPreprint
Controlled Delivery of a Neurotrophic Factor in the Adult Mouse Brain Using Engineered Microglia
Rohan Hofland, Marta Grońska-Pęski, Hiroko Nobuta…·J. Tiago Gonçalves
This study demonstrates the use of engineered microglia to deliver BDNF to the adult mouse brain, controlled by doxycycline, with enhanced engraftment via a constitutively active CSF1R mutant.
DOI 10.1101/2025.10.06.680702