Buried Ion-Pairs Reshape Folding Pathways of Artificial Proteins
Jobst Liebau, Grant Kemp, Dirk Auman, Niklas Hoja, Alexander Jussupow, Mona Baumgart, Gunnar von HEIJNE, Ville R. I. Kaila
This study shows that buried ion-pairs in artificial proteins reshape folding pathways by introducing kinetic barriers that are overcome by hydrophobic collapse and core packing.
bioRxiv · Oct 10, 2026 · PreprintBiophysics