Thorsten Friedrich

This study shows that compartmentalized oxygen generation from hydrogen peroxide enables anaerobic oxidative phosphorylation in bacteria, providing a fitness advantage in oxygen-limited environments.

This study identifies a carboxylate switch point in Complex I that mediates proton transfer and long-range PCET, showing its disruption leads to severe neurodegenerative disorders.

The paper investigates the long-range energy transduction mechanism in Complex I using simulations and experiments, identifying key redox-triggered coupling sites.