Ning Wang

The paper shows that DNA replication patterns in early mammalian embryos are established early, with late replicating regions near the nuclear lamina showing fragility and predisposing long genes to genetic changes.

VarSCAT annotates genomic variant sequence contexts, revealing that over 75% of human indels have breakpoint ambiguities and over 80% of STR region variants are indels.

The paper evaluates variant calling tools for indel detection across different NGS datasets, showing tool and sequencing setting impacts on accuracy.