Author

Noelle Burgess

Johns Hopkins University

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Neuroscience· 1

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Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

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Bo Am SeoiD· 1 shared Donghoon KimiD· 1 shared Han Seok KoiD· 1 shared Han-Byeol KimiD· 1 shared Javier Redding‐OchoaiD· 1 shared Juan Carlos TroncosoiD· 1 shared Kundlik GadhaveiD· 1 shared Liana S. RosenthaliD· 1 shared

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1 shared paperNeuroscience

Bo Am SeoORCID

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1 paper

Recent·Most cited

NeurosciencebioRxivPreprintFeb 19, 2024

Pathologic α-Synuclein-NOD2 Interaction and RIPK2 Activation Drives Microglia-Induced Neuroinflammation in Parkinson's Disease

Bo Am Seo, Seung‐Hwan Kwon, Donghoon Kim…·Han Seok Ko

This paper identifies NOD2/RIPK2 signaling as a key driver of neuroinflammation in Parkinson's disease, showing that pathological α-synuclein activates this pathway in microglia, leading to neurodegeneration and that targeting NOD2 or RIPK2 protects dopamine neurons.

3 citations

humanmouse

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