Mitochondrial function is essential for humoral immunity by controlling flux of the TCA cycle, phosphatidic acid and mTOR activity in B cells
S. Urbanczyk, O. Baris, J. Hofmann, F. Golombek, K. Castiglione, X. Meng, A. Bozec, D. Mougiakakos, S. R. Schulz, W. Schuh, U. Schloetzer-Schrehardt, T. Steinmetz, S. Brodesser, R. J. Wiesner, D. Mielenz
This study shows that mitochondrial function is critical for B cell differentiation into plasma cells by regulating TCA cycle flux, phosphatidic acid levels, and mTOR activity.
bioRxiv · Jan 14, 2021 · PreprintImmunology