X. Meng

Dynamic Localization of Leukemia Stem Cells via CXCL12 Regulates Leukemia Progression

This study shows that the CXCL12 gradient, regulated by DPP4 and GPC3, determines leukemia stem cell (LSC) localization and behavior, influencing leukemia progression.

Microsporidian Nosema bombycis secretes serine protease inhibitor to suppress host cell apoptosis via caspase BmICE

This paper identifies NbSPN14, a serine protease inhibitor secreted by Nosema bombycis, which inhibits host cell apoptosis by interacting with BmICE, providing insights into pathogen-host interactions.

Epithelial NSD2 maintains FMOs-mediated taurine biosynthesis to prevent intestinal barrier disruption

The paper shows NSD2 maintains taurine biosynthesis via FMOs in intestinal epithelial cells, preventing barrier disruption in IBD.

Toll-Like-Receptor 5 protects against pulmonary fibrosis by reducing lung dysbiosis

TLR5 deficiency is linked to pulmonary fibrosis due to its role in preventing microbial dysbiosis following lung injury.

PSMA-Guided PROTAC Degraders for Tumor-Specific Protein Degradation in Prostate Cancer

This study develops PSMA-guided PROTACs for prostate cancer, showing they selectively degrade target proteins in PSMA-overexpressing cells and improve therapeutic effects in vivo.

Sex-specific competitive social feedback amplifies the role of early life contingency in male mice

This study shows that in male mice, competition amplifies the impact of early life contingency, leading to divergent life trajectories, while this effect is absent in females.

The microtubule regulator EFA-6 forms spatially restricted cortical foci dependent on its intrinsically disordered region and interactions with tubulins

Inhibition of EV71 replication by an interferon-stimulated gene product L3HYPDH

The paper identifies L3HYPDH as an IFN-stimulated gene that inhibits EV71 replication by targeting its IRES-mediated translation.

Gut microbiota gate host exposure to cholinesterase inhibitors from dietary Solanums

The paper investigates how gut microbiota modify steroidal alkaloids from Solanum plants, affecting host exposure and physiological effects.

High-resolution lineage tracking of within-host evolution and strain transmission in a human gut symbiont across ecological scales

The paper tracks lineage evolution and transmission of Bacteroides thetaiotaomicron across hosts and ecological scales using genomic barcoding and whole-genome sequencing.

Plasmonic Enhancement of Protein Function

This study demonstrates plasmonic enhancement of protein function in living cells by coupling designed nanoparticles to Archaerhodopsin proteins, increasing fluorescence and response speed.

Discovery and engineering of the antibody response against a prominent skin commensal

The paper identifies an antibody response against Staphylococcus epidermidis and shows how it can be engineered for therapeutic vaccination.

Guild-Level Gut Microbial Alterations Associate with Non-hepatitis Virus related Hepatocellular Carcinoma

This study identifies gut microbial alterations associated with non-hepatitis virus related hepatocellular carcinoma using guild-based analysis of microbiome data.

Enterocytozoon hepatopenaei Proliferate in Procambarus clarkii: A Warning for Crayfish and Shrimp Aquaculture

This study shows that crayfish (Procambarus clarkii) can harbor and transmit the microsporidian parasite Enterocytozoon hepatopenaei, posing a risk to shrimp farming.

GABRD promotes the progression of breast cancer through CDK1-dependent cell cycle regulation

This study shows GABRD promotes breast cancer progression by regulating the cell cycle through CDK1 interaction.

Cell-autonomous targeting of arabinogalactan by host immune factors inhibits mycobacterial growth

The paper identifies galectin-9 and AG-specific antibodies that inhibit Mtb growth by targeting arabinogalactan, offering a new immunotherapeutic strategy for TB.

Comparative single-cell regulome reveals evolutionary innovations in neural progenitor cells during primate corticogenesis

The paper compares single-cell regulomes of macaque and mouse neural progenitors with human data to identify evolutionary changes in cortex development.

Estimating foraging behavior in rodents using a modified paradigm measuring threat imminence dynamics

The paper modifies a threat imminence paradigm to study foraging behavior in rodents, showing it is influenced by age, hunger, and sex.

O-GlcNAcylation of Keratin 18 coordinates TCA cycle to promote cholangiocarcinoma progression

The paper shows O-GlcNAcylation of Keratin 18 coordinates TCA cycle enzymes to promote cholangiocarcinoma progression by stabilizing K18 and altering metabolite levels.

Palmitoylation of the Hemagglutinin of Influenza B virus by ER-localized DHHC enzymes 1, 2, 4 and 6 is essential for virus replication

High-resolution structure of mouse radial spoke and its in-situ structure in ependymal cilia revealed by cryo-EM and cryo-ET

The paper presents high-resolution cryo-EM structures of mouse radial spokes and cryo-ET maps of ependymal cilia, revealing structural features and mutations linked to ciliary disorders.

Microsporidia dressing up: the spore polaroplast transport through the polar tube and transformation into the sporoplasm membrane

This study investigates the formation of the sporoplasm membrane during microsporidia spore germination, revealing that the polaroplast transforms into the sporoplasm membrane via the polar tube.

Rare SH2B3 coding variants identified in lupus patients impair B cell tolerance and predispose to autoimmunity

The paper identifies rare SH2B3 variants in lupus patients that impair B cell tolerance and increase autoimmunity risk by affecting IL-4R signaling and BAFF-R expression.

Rice stripe virus utilizes a Laodelphax striatellus salivary carbonic anhydrase to facilitate plant infection by direct molecular interaction

This study identifies a tripartite interaction between rice stripe virus, insect salivary carbonic anhydrase, and a plant protein that facilitates virus infection by enhancing callose degradation.

Expanding the family of genetically encoded voltage indicators: Insights from heliorhodopsins

This study identifies a new genetically encoded voltage indicator based on heliorhodopsins, showing improved voltage sensitivity through mutation.

Mitochondrial metabolism in primary and metastatic human kidney cancers

This study investigates mitochondrial metabolism in kidney cancers, finding that primary tumors have suppressed mitochondrial function while metastases show enhanced TCA cycle labeling.

An oral vaccine for SARS-CoV-2 RBD mRNA-bovine milk-derived exosomes induces a neutralizing antibody response in vivo

An oral mRNA vaccine using bovine milk-derived exosomes encoding SARS-CoV-2 RBD induces neutralizing antibodies in mice.

Sirt3 enhanced Bufalin sensitivity of colorectal cancer cells through P53-dependent pathway of apoptosis Sirt3 enhanced Bufalin sensitivity of colorectal cancer cells through P53-dependent pathway of apoptosis

Integrated molecular and pharmacological characterization of patient-derived xenografts from bladder and ureteral cancers identifies new potential therapies.

The paper develops patient-derived xenografts (PDXs) for bladder and ureteral cancers, identifies molecular subtypes, and shows that combined FGFR/EGFR inhibition is more effective than single-agent therapy for FGFR3-mutant tumors.

Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome

The paper investigates how strain dropouts in the gut microbiome affect community metabolism and host physiology, finding that functionally redundant strains can have significant impacts outside their niche.