Breast tumors escape endocrine therapy by ER-independent mechanisms triggered by the coordinated activities of HER2/HER3 and deacetylated FOXA1
S. Gilfillan, S. Wang, M. R. Katika…·A. Hurtado-Rodriguez
This study shows that HER2/HER3 signaling and FOXA1 deacetylation drive ER-independent growth in hormone-resistant breast tumors by altering FOXA1 chromatin binding and function.