Cancer BiologybioRxivPreprint
Farnesyltransferase inhibition overcomes the adaptive resistance to osimertinib in EGFR-mutant NSCLC
S. Figarol, C. Delahaye, R. Gence…·G. Favre
This study identifies early escapers as a rare cell population resistant to EGFR-TKi and shows that tipifarnib overcomes this resistance by targeting Rho/ROCK pathway and preventing relapse.
DOI 10.1101/2022.04.01.486707