A dynamic redox switch turns TRC40 into a chaperone protecting human cells against ATP-depleting, oxidative stress
B. Dempsey, R. Dubrall, O. Chan, K. J. Lapacz, J. Riemer, U. Jakob, K. Ulrich
This study shows TRC40 switches from an ATP-dependent targeting factor to an ATP-independent chaperone under oxidative stress, preventing protein aggregation and supporting proteostasis.
bioRxiv · Jul 10, 2024 · PreprintCell Biology