S. Su

First-male sperm precedence in polyandrous Spodoptera frugiperda allows sterile males induce population suppression

This study identifies first-male sperm precedence in fall armyworms and shows sterile males can suppress pest populations through sperm competition mechanisms.

Amino Acid-Dependent Material Properties of Tetrapeptide Condensates

This study investigates how different amino acids affect the physical properties of tetrapeptide condensates, revealing significant variations in phase behavior and material properties.

The molecular basis of pine wilt disease resistance in Pinus massoniana

This study identifies three molecular resistance strategies in Pinus massoniana cultivars against pine wood nematodes using transcriptome and metabolome profiling.

A Novel Subtype of Myeloproliferative Neoplasms Driven by a MYC-Alarmin Axis

This study identifies a MYC-S100A9 axis driving triple negative myelofibrosis and shows it is a therapeutic target.

Multitask Learning of Longitudinal Circulating Biomarkers and Clinical Outcomes: Identification of Optimal Machine-Learning and Deep-Learning Models

This study evaluates machine learning and deep learning models for predicting clinical outcomes using high-dimensional longitudinal biomarker data from a lung cancer trial, finding that MFPCA-Cox outperforms other methods.

Metabolism regulates muscle stem cell self-renewal by connecting the microenvironment and histone acetylation

The paper identifies how extracellular monosaccharide availability influences muscle stem cell self-renewal through histone acetylation and metabolic signaling.

Metabolic Reprogramming via targeting ACOD1 promotes polarization and anti-tumor activity of human CAR-iMACs in solid tumors

This study shows that targeting ACOD1 enhances the pro-inflammatory state and anti-tumor activity of human CAR-iMACs in solid tumors.

A non-invasive, fast on/off 'Odourgenetic' Method to Manipulate Physiology

This paper introduces an Odourgenetic method using Drosophila odorant receptors to non-invasively and rapidly manipulate cellular functions and behavior through inhalation of 2-pentanone.

VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis

This study shows that senescence in CD8+ T cells reduces VLA-4 expression, impairing their migration and promoting leptomeningeal metastasis in a mouse model of breast cancer.

Tumor removal limits prostate cancer cell dissemination in bone and osteoblasts induce cancer cell dormancy through focal adhesion kinase

This study shows that tumor removal increases prostate cancer cell dissemination to bones, while osteoblasts induce dormancy through focal adhesion kinase inhibition.

ADOLESCENT EXPOSURE TO LOW-DOSE THC DISRUPTS ENERGY BALANCE AND ADIPOSE ORGAN HOMEOSTASIS IN ADULTHOOD

This study shows that adolescent exposure to low-dose THC leads to metabolic changes in adulthood, including reduced fat mass and adipose dysfunction.

A single cell spatial temporal atlas of skeletal muscle reveals cellular neighborhoods that orchestrate regeneration and become disrupted in aging

The paper constructs a single cell spatial temporal atlas of skeletal muscle to reveal cellular neighborhoods involved in regeneration and their disruption in aging.

A re-emerging arbovirus in livestock in China: Early genomic surveillance and phylogeographic analysis

This study identifies Getah virus in livestock in China, analyzes its genetic diversity and dispersal patterns, and links environmental factors to its spread.

An intergeneric recombinant geminivirus causes soybean stay-green disease

This paper identifies a novel intergeneric recombinant geminivirus as the cause of soybean stay-green disease, showing it induces symptoms and can be detected in seed coats but not seeds.

Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity

This study profiles healthy human kidney cells from 19 donors to reveal sex-based transcriptional differences and tissue-specific immune features.

Multiscale profiling of enzyme activity in cancer

This paper develops methods to measure enzyme activity in cancer across multiple scales, revealing protease dysregulation and dynamic interactions between tumor cells and their microenvironment.

Total virome characterizations of game animals in China reveals a spectrum of emerging viral pathogens

The paper characterizes the virome of 1725 game animals in China, identifying 71 mammalian viruses, 45 novel, and highlighting potential zoonotic risks.

CD36 family members are TCR-independent ligands for CD1 antigen-presentingmolecules

The paper identifies CD36 family members as ligands for CD1 molecules and shows that blocking this interaction enables accurate identification of CD1-restricted T cells.

Cooperative herbivory between two important pests of rice

This study shows that two rice pests, the brown planthopper and the rice striped stem borer, cooperate by jointly attacking rice plants, improving plant quality and reducing parasitism risk.

Cryo-EM structure of the MgtE Mg2+ channel pore domain in Mg2+-free conditions reveals cytoplasmic pore opening

The paper determines the cryo-EM structure of MgtE in Mg2+-free conditions, revealing cytoplasmic pore opening and kink motions in TM2 and TM5 helices.

Activatable zymography probes enable in situ localization of protease dysregulation in cancer

This paper introduces activatable zymography probes (AZPs) to detect protease activity in cancer tissues, demonstrating their utility in classifying disease and guiding therapeutic design.

Immune Classification of Clear Cell Renal Cell Carcinoma

This study uses digital cytometry to classify immune patterns in clear cell renal cell carcinomas, identifying four distinct immune cell composition groups and their associations with clinical outcomes.

Accurate Diagnosis of Colorectal Cancer Based on Histopathology Images Using Artificial Intelligence

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

Enzalutamide-induced PTH1R-mediated TGFBR2 decrease in osteoblasts contributes to resistance in prostate cancer bone metastases

Structural Basis For The Specific Recognition Of DSR By The YTH Domain Containing Protein Mmi1

The paper reports the crystal structure of the YTH domain of Mmi1 bound to DSR-containing RNA, revealing the mechanism of specific RNA recognition and its distinct function compared to other YTH domain proteins.

Molecular Basis For The Specific And Multivariate Recognitions Of RNA Substrates By Human hnRNPA2/B1

This study determines the crystal structures of hnRNPA2/B1's RRM domains bound to RNA substrates, revealing sequence-specific recognition and suggesting a matchmaker mechanism, but not m6A binding.