Author

U. Jakob

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

J. Lempart· 2 shared A. Dhabaria· 1 shared A. Franz· 1 shared A. Sutter· 1 shared B. Ueberheide· 1 shared D. Southworth· 1 shared E. K. Quarles· 1 shared E. P. Skaar· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersCell Biology

J. Lempart

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Polyphosphate Functions In Vivo as Iron Chelator and Fenton Inhibitor

U. Jakob, F. Beaufay, E. K. Quarles, A. Franz, O. Katamanin, W. Y. Wholey

The paper shows polyphosphate prevents iron-induced oxidative stress by chelating iron and inhibiting the Fenton reaction in bacteria.

bioRxiv · Apr 14, 2020Microbiology

Mycobacterium tuberculosis Rv0991c is a redox-regulated molecular chaperone

S. H. Becker, K. Ulrich, A. Dhabaria, B. Ueberheide, W. N. Beavers, E. P. Skaar, L. M. Iyer, L. Aravind, U. Jakob, K. H. Darwin

This paper identifies Rv0991c in M. tuberculosis as a redox-regulated molecular chaperone essential for virulence, functioning similarly to Hsp33 in E. coli.

bioRxiv · Mar 5, 2020Microbiology

Mechanistic Insights into the Protective Roles of Polyphosphate Against Amyloid Cytotoxicity

J. Lempart, E. Tse, J. A. Lauer, M. I. Ivanova, A. Sutter, N. Yoo, P. Huettemann, D. Southworth, U. Jakob

This study investigates how polyphosphate (polyP) affects α-synuclein fibril formation and cytotoxicity, finding that polyP alters fibril morphology and reduces membrane interaction, suggesting potential therapeutic applications.

bioRxiv · Jul 16, 2019Cell Biology

Polyphosphate initiates tau aggregation through intra- and intermolecular scaffolding

S. P. Wickramasinghe, J. Lempart, H. E. Merens, J. Murphy, U. Jakob, E. Rhoades

This study shows polyphosphate initiates tau aggregation by altering its conformation and enabling noncovalent cross-linking.

bioRxiv · Mar 25, 2019Biophysics