Structure and mechanism of LARGE1 matriglycan polymerase
S. Joseph, N. J. Schnicker, Z. Xu, T. Yang, J. Hopkins, M. Watkins, S. Chakravarthy, O. Davulcu, M. E. Anderson, D. Venzke, K. P. Campbell
The paper determines the cryo-EM structure of LARGE1 and shows it functions as a dimer to processively polymerize matriglycan on dystroglycan using alternating active sites.
bioRxiv · May 12, 2022Biochemistry