TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets
D. Bestle, M. R. Heindl, H. Limburg, T. Van Lam van, O. Pilgram, H. Moulton, D. A. Stein, K. Hardes, M. Eickmann, O. Dolnik, C. Rohde, S. Becker, H.-D. Klenk, W. Garten, T. Steinmetzer, E. Bottcher-Friebertshauser
This study shows TMPRSS2 and furin are both critical for SARS-CoV-2 activation in human airway cells and that inhibiting them can effectively block virus replication.
bioRxiv · Apr 15, 2020 · PreprintMicrobiology