Author

K. Hardes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:proteomics· 2 Approach:biophysical modeling· 1 Organism:Drosophila· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

T. Steinmetzer· 2 shared A. Paas· 1 shared A. Pasquato· 1 shared A. Roulin· 1 shared A. Stahlhut· 1 shared A. Vilcinskas· 1 shared C. Fedeli· 1 shared C. Rohde· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

T. Steinmetzer

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Engineering a wolf spider A-family toxin towards increased antimicrobial activity but low toxicity

L. Dersch, A. Stahlhut, J. Eichberg, A. Paas, K. Hardes, A. Vilcinskas, T. Lueddecke

The paper enhances antimicrobial activity of a spider venom peptide while maintaining low toxicity through bioengineering.

bioRxiv · Mar 4, 2024Bioengineering

TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets

D. Bestle, M. R. Heindl, H. Limburg, T. Van Lam van, O. Pilgram, H. Moulton, D. A. Stein, K. Hardes, M. Eickmann, O. Dolnik, C. Rohde, S. Becker, H.-D. Klenk, W. Garten, T. Steinmetzer, E. Bottcher-Friebertshauser

This study shows TMPRSS2 and furin are both critical for SARS-CoV-2 activation in human airway cells and that inhibiting them can effectively block virus replication.

bioRxiv · Apr 15, 2020 · PreprintMicrobiology

A novel cell-based sensor detecting the activity of individual basic proprotein convertases

K. I. Low, K. Hardes, C. Fedeli, N. G. Seidah, D. B. Constam, A. Pasquato, T. Steinmetzer, A. Roulin, S. Kunz

The paper introduces PCific, a cell-based sensor to screen and distinguish inhibitors of individual basic proprotein convertases in mammalian cells.

bioRxiv · Nov 6, 2018Biochemistry